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Respiratory System

Events/ Steps in Respiration

There are no strict demarcations of events involved in the process of respiration. It is a very complex process of several biochemical and physical processes. But for a general understanding on what goes on, we shall study under the following heads.
Pathway of air:
Let us observe the pathway of air from nostril to alveolus.
Nostrils: Air usually enters the body through the nostrils
Nasal cavity: Air is filtered. The moist surface of the lining of the nasal cavity, and the hairs growing from its sides, remove some of the tiny particles of dirt in the air. In addition, as the inhaled air passes through the nasal cavity, its temperature is brought close to that of the body, and it takes up water vapour so that it becomes more moist than before.
Pharynx: Warming and moistening goes on in this common passage of digestive and respiratory system. Epiglottis, a flap like muscular valve controls movement of food arid air towards their respective passages.
Larynx: This stiff box contains our vocal cords. When air passes out of the lungs and over the vocal cords, it causes them to vibrate. This produces sounds on the basis of our speech, song etc.
Trachea: Wind pipe channeling air to lungs. Touch your throat to feel the tube like structure.
Bronchus: At its lower end the trachea or the wind pipe divides into two bronchi-one leading to each lung.
Bronchiloes:  Each bronchi is further divided into smaller and smaller branches called bronchioles.
Alveolus: These finally terminate in clusters of air sacs called alveoli in the lungs which are very small and numerous. Gaseous exchange takes place here as blood capillaries take up oxygen and expel carbon dioxide.
Blood: Carries oxygen, to each and every cell of the body and collects CO2 from them.

Mechanism of respiration in human beings:
We know that breathing is the process of inhaling and exhaling. The organs involved are mainly the lungs. You can’t see your lungs, but it’s easy to feel them in action. Put your hands on your chest and breathe in very deeply. You will feel your chest getting slightly bigger. Now breathe out the air, and feel your chest return to its regular size. You’ve just felt the power of your lungs! The lungs themselves can neither draw in air nor push it out. Instead, the chest wall muscles and another flexible flattened muscle called diaphragm helps the lungs in moving air into and
out of them.
The chest wall is made up of ribs, muscles, and the skin. The ribs are Attached at an angle to the spine (if you run your finger along one of your ribs, you will notice that It extends downward from the spine). When we inhale, the chest wall moves up and expands. This causes an increase in the volume of the chest cavity.
The chest wall is made up of ribs, muscles, and the skin. The ribs are attached at an angle to the spine (if you run your finger along one of your ribs, you will notice that it extends downward from the spine). When we inhale, the chest wall moves up and expands. This causes an increase in the volume of the chest cavity.
The diaphragm may be imagined as the ‘floor’ if you think of the chest cavity as a “room.” When the diaphragm is relaxed when we breath out, it is in the shape of a dome with the convex side of the dome extending into the chest cavity. When the diaphragm contracts during inhalation it flattens out a bit or the dome moves downward. As a result, the volume of the chest cavity is increased.
When the diaphragm flattens and the volume of the chest cavity is increased, its internal pressure decreases and the air from the outside rushes into the lungs. This is inspiration (inhalation).
Then the reverse occurs. The chest wall is lowered and moves inward, and the diaphragm relaxes and assumes its dome shape. These changes increase the pressure on the lungs; their elastic tissue contracts and squeezes the air out through the nose to the external atmosphere. This is expiration (exhalation).

Gas
% in inhaled air
% in exhaled air
Oxygen
21
16
Carbon dioxide
0.03
4.4
Nitrogen
78
78


Transportation of gases:
When oxygen present in the air is within normal limits (around 21%) then almost all of it is carried in the blood by binding to haemoglobin, a protein (quite like chlorophyll, the only major difference being it has iron in place of magnesium as in chlorophyll) present in the red blood cells. As oxygen is diffused in the blood, it rapidly combines with the haemoglobin to form oxyhaemoglobin. Not only haemoglobin can combine with oxygen, but the reverse can also happen to yield a molecule of haemoglobin and oxygen.
Carbon dioxide is usually transported as bicarbonate, while some amount of it combines with haemoglobin and rest is dissolved in blood plasma. Study the following equation for better understanding.
Hb+O2 -------------àHbO2(in lungs)

HbO2 ---------------------àHb+ O 2(in tissues)

Cellular respiration:
The term cellular respiration refers to the pathway by which cells release energy from the chemical bonds of food molecules that enter them. It provides that energy for the essential processes of life. So living cells must carry out cellular respiration. It Can be in the presence of oxygen that is ‘aerobic respiration’ or in its absence that is ‘anaerobic respiration (fermentation)’. Cellular respiration in prokaryotic cells like that of bacteria occurs within the cytoplasm. In eukaryotic cells cytoplasm and mitochondria are the sites of the reactions. The produced energy is stored in mitochondria in the form of ATP. That is why mitochondria are called “power houses of cell”.
The exact chemical details of the breakdown of sugar or other foods within a living cell does not take place as a single reaction, but occurs in a series of small steps.
How does this affect the energy release? As the change in the chemical nature of the molecule from one stage to the next is slight, in any step small amount of energy is released. The complete breakdown of a sugar molecule with the release of all its available energy involves a series of different chemical reactions.
From the breakdown of glucose the energy is released and stored up in a special compound, known as ATP (adenosine triphosphate). It is a small parcel of chemical energy. The energy currency of these cells is ATP an energy rich compound that is capable of supplying energy wherever needed within the cell. Each
ATP molecule gives 7200 calories of energy. This energy is stored in the form of phosphate bonds. If the bond is broken the stored energy is released.
• Do cells of alveoli or lungs also require oxygen to carry out cellular respiration? Why/Why not?
In short, at cellular level we could have the following pathways starting with glucose (It is one example, remember that there are other components of food as well).

·      By “respiratory System” we usually mean the passages that transport air to the lungs and to the microscopic air sacs in them, called alveoli (where gases are exchanged) and vice versa.
·       The term ‘respiration’ refers to the whole chain of processes from the inhalation of air to the use of oxygen in the cells.
·         Lavoisier found that the air that we breathe out precipitated lime water
·         Air passes from nostrils to nasal cavity to pharynx, larynx, trachea, and bronchi, bronchioles to alveoli and blood and back through the same route.
·       Gas exchange in the lungs takes place in the tiny air sacs called alveoli in the lungs. The lungs have millions of alveoli and each lies in contact with capillaries.
·       Diaphragm is a muscular tissue present at the floor of the chest cavity.
·         During inspiration (inhalation) the volume of the chest cavity is increased as the diaphragm contracts and dome flattens out, its internal pressure decreases and the air from the outside rushes into the lungs.
·         During expiration, the chest wall is lowered and moves inward, and the diaphragm relaxes and assumes its dome shape. These changes increase the pressure on the lungs; their elastic tissue Contracts and squeezes the air out through the nose to the external atmosphere.
·         Air is filtered in the nasal cavity and the whole length of the trachea.
·    The moist surface of the lining of the nasal cavity, and the hairs growing from its sides, remove son of the tiny particles of dirt in the air. In addition, as the inhaled air passes through the nasal cavity, it temperature is brought close to that of the body, and it takes up water vapour. So that it becomes more moist than before.
·    Pharynx is a common passage of digestive and respiratory system. Epiglottis, a flap like muscular valve controls movement of air and food towards their respective passages.
·     Larynx is a stiff box like structure containing our vocal cords. When air passes out of the lungs and over the vocal cords, it causes them to vibrate. This produces sounds on the basis of our speech, song etc.
·         Trachea is the wind pipe channeling air to lungs.
·      At its lower end the trachea or the wind pipe divides into two bronchi-one leading to each lung.
·       The bronchi divide into smaller and smaller branches called bronchioles.
·       These finally terminate in clusters of air sacs called alveolus in the lungs which are very small and numerous. Gaseous exchange takes place here as blood capillaries take up oxygen and expel carbon dioxide here.
·      Aerobic respiration occurs in adequate supply of air producing a lot of energy, carbon dioxide and water.
·         Anaerobic respiration and fermentation occurs in inadequate supply or absence of oxygen to produce energy.
·  Cells may resort to the breakdown of 3 carbon compound, pyruvate, aerobically or anaerobically depending upon the availability of oxygen. Usually in multicellular organisms cells fail to carry am the process of anaerobic respiration for long.
·         Respiration is not essentially a process of combustion differ due to following reasons
Glucose must be burnt at high temperature in the laboratory to liberate energy, if it happened in our cells, all cells would be burnt.
Once glucose starts burning we can’t stop the process easily, but living cells are able to exercise control over the sort of burning of glucose in the presence of oxygen.
Water normally stops combustion from taking place while cells contain a lot of water and respiration still goes on.
·       Photosynthesis and respiration appear to be opposing reactions, but both have very different biochemical pathways and are essential for a plant’s metabolism,
·  Photosynthesis takes place in the chloroplast to produce sugars, starches and other carbohydrates for the plant’s metabolic needs.
·      Cellular respiration occurs in mitochondria where mainly these carbohydrates are “burned” to produce chemical energy to do work at the cellular level.

The Indian ayurvedic physician. Patanjali developed a scientific breathing practice called Yogabhyasa. Maharshi Patanjali proposed a theory called Astanga yoga. He was introduced 195 yogic principles in, eight divisions.
1. Yania (Social disipline),
2. Niyama (Individual disipline),
3. Asana (Body posture),
4. Pranayama (Expansion of vital energy),
5. Prathyahara (With drawal of senses),
6. Dharana (Concentration),
7. Dhya.na (Meditation),
8. Samadi (Self realisation).